Selected publications
1. Santos RF, Oliveira L, Brown MH, Carmo AM. Domain-specific CD6 monoclonal antibodies identify CD6 isoforms generated by alternative-splicing. Immunology, 2019.
2. Breuning J., Brown M. H. A sequence conserved between CD5 and CD6 binds a FERM domain and exerts a restraint on T cell activation. Immunology, 2018.
3. Breuning J., Philip B., Brown M. H. Addition of the C-terminus of CD6 to a chimeric antigen receptor enhances cytotoxicity and does not compromise expression. Immunology, 2018.
4. Garner, L. I., Hartland, A., Breuning, J. and Brown, M. H., CD6 mAbs differ in epitope, kinetics and mechanism of action. Immunology, 2018. 155: p. 273-282.
5. Breuning, J., and Brown, M.H. (2017). T cell costimulation by CD6 is dependent on bivalent binding of a GADS/SLP-76 complex. Mol Cell Biol, 2017. 37(11): p. 1-12.
6. Margraf, S., et al., A polymorphism in a phosphotyrosine signalling motif of CD229 (Ly9, SLAMF3) alters SH2 domain binding and T-cell activation. Immunology, 2015. 146: p. 392-400.
7. Chappell, P.E., et al., Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction. Structure, 2015. 23(8): p. 1426-36.
8. Brown, M.H., CD6 as a cell surface receptor and as a target for regulating immune responses. Curr Drug Targets, 2016. 17(6); p.619-29.
9. Wilson, T.J., et al., Fine specificity and molecular competition in SLAM family receptor signalling. PLoS One, 2014. 9(3): p. e92184.
10. Mihrshahi, R. and M.H. Brown, Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling. J Immunol, 2010. 185(12): p. 7216-22.
11. Brown, M.H. and E. Lacey, A Ligand for CD5 is CD5. Journal of Immunology, 2010. 185(10): p. 6068-6074.
12. Mihrshahi, R., A.N. Barclay, and M.H. Brown, Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells. J Immunol, 2009. 183(8): p. 4879-86.
13. Clarkson, N.G. and M.H. Brown, Inhibition and Activation by CD244 Depends on CD2 and Phospholipase C-{gamma}1. J Biol Chem, 2009. 284(37): p. 24725-34.
14. Clarkson, N.G., et al., Direct and Indirect Interactions of the Cytoplasmic Region of CD244 (2B4) in Mice and Humans with FYN Kinase. J Biol Chem, 2007. 282(35): p. 25385-94.
15. Hassan, N.J., et al., CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76. Mol Cell Biol, 2006. 26(17): p. 6727-38. Corrections. Mol Cell Biol 2009;29:3452 & 2019;39.
16. Hassan, N.J., A.N. Barclay, and M.H. Brown, Frontline: Optimal T cell activation requires the engagement of CD6 and CD166. Eur J Immunol, 2004. 34(4): p. 930-40.
17. Hutchings, N.J., et al., Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. J Biol Chem, 2003. 278(25): p. 22396-403.
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